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KMID : 0358220060330020097
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Korean Journal of Fertility and Sterility
2006 Volume.33 No. 2 p.97 ~ p.104
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Association of the COMT Gene Polymorphism with the Risk of PCOS in Korean Women
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Lee Ji-Young
Cha Yun-Jeong
Hur Sung-Eun
Kwon Han-Sung
Lee Sun-Joo
Sohn In-Sook
Kim Soo-Nyung
Sung Yeon-Ah
Chung Hye-Won
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Abstract
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Objective: To investigate whether polymorphism of Catechol-O-methyltransferase (COMT) gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women.
Methods: One hundred and thirty-six PCOS patients and eighty four controls were enrolled. Blood samples were collected from the patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited as control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals’ genotype.
Results: In women with COMTLL genotype, there was decreased PCOS risk and this difference was statistically significant (OR 0.24, 95% CI 0.11~0.51).
Conclusion: The results suggest that the COMTLL genetic polymorphism might be associated with PCOS risk in Korean women.
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KEYWORD
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COMT, PCOS, Polymorphism
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